KIM-1 (kidney injury molecule 1) in the urine of renal cell carcinoma patients

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Abstract

Objective: to assess the potential clinical significance of KIM-1 (kidney injury molecule 1) as a urinological marker for kidney cancer.

Materials and methods. An enzyme-linked immunosorbent assay was used to assess urinary KIM-1 (uKIM-1 — kidney injury molecule 1) levels in 67 patients with renal cell carcinoma (RCC) and 36 healthy volunteers (a control group).
Results. Both in patients and in healthy individuals, uKIM-1 levels were age independent. A difference between mean uKIM-1 values in RCC patients (2.4 ± 0.2 ng/ml) and the control group (0.7 ± 0.1 ng/ml) was statistically significant (p <0.0001). In RCC patients the higher uKIM-1 level was observed at more advanced clinical disease stages: the values increasedfrom 2.0 ± 0.2 ng/ml at the stage I and 3.0 ± 0.5 ng/ml at the stage II—III to 4.4 ± 1.2 ng/ml at the stage IV. In the group of patients with stage IRCC, most representative by the number of cases (n = 44) the uKIM-1 levels correlated with the tumor size and were increased in patients with different histological subtypes of the tumor, including clear cell, papillary and chromophobe RCC. After nephrectomy, a monotonous decrease in uKIM-1 level was observed, and after 6 days its values approached the mean value in the control group. Two days after kidney resection, uKIM-1 increased and then decreased, remaining elevated after 6 days.
Conclusion. This study demonstrates that uKIM-1 can be attributed to potentially significant urine tumor-associated markers of RCC.

About the authors

K. Yu. Kanukoev

P.A. Hertzen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Author for correspondence.
Email: dr.kanukoev@yandex.ru
ORCID iD: 0000-0001-8160-2289
3 2 nd Botkinskiy Proezd, Moscow 125284. Russian Federation

N. S. Sergeeva

P.A. Hertzen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Center, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: prognoz.01@mail.ru
ORCID iD: 0000-0001-7406-9973

3 2 nd Botkinskiy Proezd, Moscow 125284; 1 Ostrovityanovа St., Moscow 117997.

Russian Federation

T. A. Karmakova

P.A. Hertzen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: prognoz.06@mail.ru
ORCID iD: 0000-0002-8017-5657
3 2 nd Botkinskiy Proezd, Moscow 125284. Russian Federation

N. V. Marshutina

P.A. Hertzen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: prognoz.06@mail.ru
ORCID iD: 0000-0003-2997-4936
3 2 nd Botkinskiy Proezd, Moscow 125284. Russian Federation

M. P. Solokhina

P.A. Hertzen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: prognoz.06@mail.ru
ORCID iD: 0000-0003-0676-600X
3 2 nd Botkinskiy Proezd, Moscow 125284. Russian Federation

K. M. Nyushko

P.A. Hertzen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Center, Ministry of Health of Russia

Email: kirandja@yandex.ru
ORCID iD: 0000-0002-4171-6211
3 2 nd Botkinskiy Proezd, Moscow 125284. Russian Federation

B. Ya. Alekseev

National Medical Research Radiological Center, Ministry of Health of Russia; Medical Institute of Continuing Education, Moscow State University of Food Production

Email: byalekseev@mail.ru
ORCID iD: 0000-0002-1353-2271

4 Koroleva St., Obninsk 249031; 11 Volokolamskoe Shosse, Moscow 125080.

Russian Federation

A. D. Kaprin

National Medical Research Radiological Center, Ministry of Health of Russia

Email: kaprin@mail.ru
ORCID iD: 0000-0001-8784-8415
4 Koroleva St., Obninsk 249031. Russian Federation

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