Nephroblastoma in adults

Abstract

Nephroblastoma (NB), a childhood embryonic tumor, accounts for less than 1% of all neoplasms in adults. The algorithm of an examination of patients aged above 14 years who has suspected NB should include angiography in addition to ultrasound computed tomography and computed tomography. Verification of its diagnosis in adults before therapy requires fine-needle tumor biopsy. Treatment for NB in adults should be multimodality and include neoadjuvant chemotherapy, primary tumor removal, and subsequent chemoradiation therapy. The prognosis is fair in patients over 14 years of age who had a localized NB and poor in those with locally extended and disseminated tumors. It is necessary to perform multicenter studies in order to develop an optimal therapeutic algorithm and to improve the results of treatment for NB in adults.