Role of the genetic factors in the formation of malignant neoplasia of urinary bladder

Abstract

Malignant neoplasias are one of the most complicated medical and social problems. According to WHO data, about 3% of the all malignant neoplasias are comprised of bladder cancer (BC). According to numerous epidemiological studies, up to 90% of the all malignant neoplasias arise due to hostilities impacts and accumulation of genotoxic substances as well as carcinogens and mutagens. The main genetic factors are considered and their impact on the bladder malignant neoplasias formation is analysed in the article. The given data testify to the important role of the xenobiotics detoxication enzymes, gene methylation state, cytokines activity in the development of the tumor processes and specifically BC.