Intraosseous chemotherapy in the treatment of invasive bladder carcinoma

Abstract

Neoadjuvant chemotherapy (CT) with cisplatin administered intraosseously into the pubic bone in patients with invasive bladder carcinoma (Т2—4N0M0) was most effective in patients with circular involvement of the bladder neck, even in large tumors of 5—7 cm. Out of 4 patients with this site of a tumor, full regression without further treatment was achieved in one patient, transurethral resection was performed in 3 patients with 75% tumor regression. In multiple bladder tumor lesions involving the bladder neck, the degree of regression was not greater than 40%. The therapeutic efficiency of intraosseous CT with cisplatin was 54% with acceptable toxicity.