Fluorescent in situ hybridization: clinical use in oncourology

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Abstract

Tumor markers for diagnosis of bladder cancer and defining the prognosis of the disease have been actively studied for past decade. FISH-study demonstrates the highest sensitivity and specificity. Abbot Company has developed a diagnostic test system «UroVision» which includes colored DNA-probes referring to 3, 7, 17 and 9p21 chromosomes. This system use provides clinicians with insights into an early diagnosis, prognosis and monitoring of efficacy of anticancer therapy.

About the authors

S. V. Bashkatov

State Enterprise Medical Radiological Research Center, Russian Academy of Medical Sciences

Author for correspondence.

Department of Radiotherapy and Surgery of Urologic Diseases

Obninsk Russian Federation

A. V. Sevankaev

State Enterprise Medical Radiological Research Center, Russian Academy of Medical Sciences

Radiation Cytogenetic Laboratory

Obninsk

Russian Federation

O. B. Karyakin

State Enterprise Medical Radiological Research Center, Russian Academy of Medical Sciences

Department of Radiotherapy and Surgery of Urologic Diseases

Obninsk Russian Federation

G. F. Mihaylova

State Enterprise Medical Radiological Research Center, Russian Academy of Medical Sciences

Radiation Cytogenetic Laboratory

Obninsk

Russian Federation

Ye. V. Golub

State Enterprise Medical Radiological Research Center, Russian Academy of Medical Sciences

Radiation Cytogenetic Laboratory

Obninsk

Russian Federation

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