Email this article Clinical application of FISH method in the early diagnostics of superficial bladder cancer
- Authors: Sevankaev A.V.1, Lushnikov E.F.1, Karyakin O.B.1, Mikhailova G.F.1, Gorban N.A.1, Bashkatov S.V.1, Goloub E.V.1, Shkavrova T.G.1, Tsepenko V.V.1
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Affiliations:
- Medical Radiological Research Centre of Russian Academy of Medical Sciences
- Issue: Vol 4, No 4 (2008)
- Pages: 61-65
- Section: DIAGNOSIS AND TREATMENT OF URINARY SYSTEM TUMORS. URINARY BLADDER CANCER
- Published: 30.12.2008
- URL: https://oncourology.abvpress.ru/oncur/article/view/1044
- DOI: https://doi.org/10.17650/1726-9776-2008-4-4-61-65
- ID: 1044
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Abstract
Patients with primary diagnosis of bladder cancer (42 persons) were studied. FISH analysis performed in all patients showed the following results: 39 (93%) patients were FISH positive and 3 (7%) were FISH negative. The molecular cytogenetic criterion for determining the grade of differentiation of Ta and T1 tumors — chromosomal hyperploidy in morphologically abnormal cells, was suggested. All patients demonstrating increased amount (more than 26%) of abnormal cell with hyperploidy of chromosomes 3, 7 and 17 were found to have high grade malignancies.
About the authors
A. V. Sevankaev
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Author for correspondence.
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationE. F. Lushnikov
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationO. B. Karyakin
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationG. F. Mikhailova
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationN. A. Gorban
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationS. V. Bashkatov
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationE. V. Goloub
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationT. G. Shkavrova
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationV. V. Tsepenko
Medical Radiological Research Centre of Russian Academy of Medical Sciences
Department of radiotherapy and surgery of urologic disorders, clinical morphologic department, laboratory of molecular cytogenetics
Russian FederationReferences
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